Impact of obesity on outcome of severe bacterial infections.

IntroductionObesity is a rapidly growing global health concern with considerable negative impact on life-time expectancy.It has yet not been clarified if and how obesity impacts outcomes of severe bacterial infections.The aim of this study was to determine how body mass index impacts outcome of severe bacterial infections in a well-defined populati

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Establishment of a well-characterized SARS-CoV-2 lentiviral pseudovirus neutralization assay using 293T cells with stable expression of ACE2 and TMPRSS2.

Pseudoviruses are useful surrogates for highly pathogenic viruses because of their safety, genetic stability, and scalability for screening assays.Many different pseudovirus platforms exist, each with different Snacks advantages and limitations.Here we report our efforts to optimize and characterize an HIV-based lentiviral pseudovirus assay for scr

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